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上海信裕生物科技有限公司
SIRT3抗体

SIRT3抗体

商家询价

产品名称： SIRT3抗体

英文名称： SIRT3Antibody

产品编号： XY 10099-1-

产品价格： null

产品产地： 中国/美国

品牌商标： XYbscience

更新时间： 2023-08-17T09:55:27

使用范围： WB,ELISA,IHC-P,IHC-F,IF

上海信裕生物科技有限公司
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 SIRT3抗体Applications

In-house applications ELISA, WB     Application not tested? Please see our Guarantee.
Species specificity Human,Mouse,Rat; other species not tested.
Images
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  • 10099-1-AP;mouse liver tissuemouse liver tissue were subjected to SDS PAGE followed by western blot with 10099-1-AP( SIRT3 Antibody) at dilution of 1:300
Positive WB detected in Mouse liver tissue, human spleen tissue, mouse kidney tissue, mouse skeletal muscle tissue
Recommended dilution WB : 1:200-1:1000
 SIRT3抗体Application key: WB = Western blotting, IHC = Immunohistochemistry, IF = Immunofluorescence,
IP = Immunoprecipitation
Product Information
Source Rabbit Purification method Antigen affinity purification
Isotype IgG Storage PBS with 0.1% sodium azide and 50% glycerol pH 7.3. Store at -20oC.
Immunogen Information SIRT3抗体
Immunogen SIRT3 fusion protein ag0148 Full name Sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)
Calculated molecular
weight		 44 kDa Observed molecular 
weight		 28 kDa
GenBank accession 
number		 BC001042 Gene ID (NCBI) 23410
Gene symbol SIRT3 Synonyms HSIRT3, SIR2 like protein 3, SIR2L3, SIRT3
Background

Sirtuins are NAD+-dependent histone/protein deacetylases (HDAC) and SIRT3 is the only sirtuin whose increased expression has been shown to correlate with an extended life span in humans. It is localized in the mitochondrial matrix, where it regulates the acetylation levels of metabolic enzymes, including acetyl coenzyme A synthetase 2. SIRT3 is stress-responsive and its increased expression protects myocytes from genotoxic and oxidative stress-mediated cell death. full-length hSIRT3 (44 kDa) is an inert protein and that it is activated inside the mitochondria following deletion of 142 amino acids of the N-terminal segment. This processed form of SIRT3 is approximately 28 kDa and possesses deacetylase activity. The full SIRT3 is a 44 kDa protein and is processed by mitochondrial processing peptidase (MPP) to give a 28 kDa product. SIRT3抗体

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