FITC标记的9号染色体开放阅读框46抗体
产品名称： FITC标记的9号染色体开放阅读框46抗体
英文名称： Anti-C9ORF46/FITC
产品编号： HZ-9489R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： ICC=1:50-200 IF=1:50-200
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Rabbit Anti-C9ORF46/FITC Conjugated antibody
FITC标记的9号染色体开放阅读框46抗体
| 产品编号 | bs-9489R-FITC |
| 英文名称 | Anti-C9ORF46/FITC |
| 中文名称 | FITC标记的9号染色体开放阅读框46抗体 |
| 别 名 | FLJ14688; AD025; Chromosome 9 open reading frame 46; FLJ39176; Hypothetical protein LOC55848; MDS030; transmembrane protein C9orf46; Uncharacterized hematopoietic stem/progenitor cells protein MDS030; PLRKT_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 细胞生物 发育生物学 神经生物学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | ICC=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 17kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C9ORF46 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: C9orf46 is a 147 amino acid transmembrane protein. The gene encoding C9orf46 maps to human chromosome 9, which consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. Function: Receptor for plasminogen. Regulates urokinaseplasminogen activator-dependent and stimulates tissue-typeplasminogen activator-dependent cell surface plasminogenactivation. Proposed to be part of a local catecholaminergic cellplasminogen activation system that regulates neuroendocrineprohormone processing. Involved in regulation of inflammatoryresponse; regulates monocyte chemotactic migration and matrixmetallproteinase activation, such as of MMP2 and MMP9. Subunit: Interacts with PLAT and PLAUR (By similarity). Subcellular Location: Cell membrane; Multi-pass membrane protein.Note=Colocalizes on the cell surface with urokinase plasminogenactivator surface receptor/PLAUR (By similarity). Tissue Specificity: Expressed in peripheral blood cells andmonocytes. Expressed in adrenal medulla. Database links: Entrez Gene: 55848 Human SwissProt: Q9HBL7 Human SwissProt: Q9D3P8 Mouse Unigene: 584242 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
C9OF46是一个147氨基酸跨膜蛋白。编码C9ORF46的基因定位于人类9号染色体，由约1亿4500万个碱基和4%个人类基因组组成，编码近900个基因。认为在性别决定中起作用的是，9P末端的缺失可导致男性与女性性别逆转的发展，一个具有男性X、Y基因型的女性的表型。遗传性出血性毛细血管扩张症，其特征是由有害的血管缺陷，与编码EngGLN蛋白的染色体9基因有关。家族性失代偿也通过基因IKBKAP与9号染色体相关。值得注意的是，9号染色体包含最大的干扰素家族基因簇。染色体9与易位的22号染色体相关，导致BCR-ABL融合蛋白在白血病中的异常生成。