FITC标记的染色质结合蛋白Cbx8抗体
产品名称： FITC标记的染色质结合蛋白Cbx8抗体
英文名称： Anti-Cbx8/FITC
产品编号： HZ-3500R-FITC
产品价格： null
产品产地： 中国/上海
品牌商标： HZbscience
更新时间： 2023-08-17T10:24:20
使用范围： IF=1:50-200
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Rabbit Anti-Cbx8/FITC Conjugated antibody
FITC标记的染色质结合蛋白Cbx8抗体
| 英文名称 | Anti-Cbx8/FITC |
| 中文名称 | FITC标记的染色质结合蛋白Cbx8抗体 |
| 别 名 | Chromobox protein homolog 8; HPC3; Pc3; Polycomb 3 homolog; RC1; Rectachrome 1; CBX8_HUMAN. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 肿瘤 免疫学 信号转导 干细胞 转录调节因子 结合蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 43kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Cbx8 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Cbx8, also known as Pc3, is a member of the Polycomb gene family and is required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. Cbx8 contains a chromodomain and is able to modify chromatin and histones. Function: Component of a Polycomb group (PcG) multiproteinPRC1-like complex, a complex class required to maintain thetranscriptionally repressive state of many genes, including Hoxgenes, throughout development. PcG PRC1 complex acts via chromatinremodeling and modification of histones; it mediatesmonoubiquitination of histone H2A 'Lys-119', rendering chromatinheritably changed in its expressibility. Subunit: Component of a PRC1-like complex. Interacts with RING1RNF2, PCGF1, PCGF2, PCGF3, BMI1, PCGF5 AND PCGF6. Interacts withMLLT3 and histone H3. Interacts with PHC2 (By similarity). Subcellular Location: Nucleus. Similarity: Contains 1 chromo domain. Database links: Entrez Gene: 506458 Cow Entrez Gene: 57332 Human Entrez Gene: 30951 Mouse Entrez Gene: 303731 Rat SwissProt: Q9HC52 Human SwissProt: Q9QXV1 Mouse Unigene: 387258 Human Unigene: 99953 Mouse Unigene: 43722 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications |
CBX8，又称PC3，是多梳基因家族的成员，在整个发育过程中，需要维持许多基因（包括Hox基因）的转录抑制状态。CBX8含有染色质，能够修饰染色质和组蛋白。